Francois Sichel

Pr de toxicologie

UFR Santé, Université de Caen-Normandie et CLCC François Baclesse

Thèmes de recherche :
– Cancérogenèse chimique, toxicologie génétique des polluants de l’environnement
– Toxicité de la radiothérapie

Responsabilités :
Directeur de l’UR ABTE

Responsable du parcours de master « développement clinique du médicament » et du département de Biochimie-Toxicologie de la Faculté des Sciences Pharmaceutiques de Caen.

Vice-président de la Société Française de Toxicologie Génétique (SFTG)

Sélection de publications récentes :

  • Comparative study of diesel and biodiesel exhausts on lung oxidative stress and genotoxicity in rats. T. DOUKI, C. CORBIERE, D. PRETERRE, P.J. MARTIN, V. LECUREUR, V. ANDRE, Y. LANDKOCZ, I. POTTIER, V. KERAVEC, O. FARDEL, S. MOREIRA-REBELO, D. POTTIER, C. VENDEVILLE, F. DIONNET, P. GOSSET, S. BILLET, C. MONTEIL, F. SICHEL. Env. Poll. 2018, 235, 514-524.
  • Production of early and late nuclear DNA damage and extracellular 8-oxodG in normal human skin fibroblasts after carbon ion irradiation compared to X-rays. V. PREVOST, F. SICHEL, I. POTTIER, A. LEDUC, S. LAGADU, C. LAURENT. Toxicol In Vitro. 2018 Jun 4. doi: 10.1016/j.tiv.2018.06.004.
  • Impact of after-treatment devices and biofuels on diesel exhausts genotoxicity in A549 cells exposed at air-liquid interface. C. BARRAUD, C. CORBIERE, I. POTTIER, E. ESTACE, K. BLANCHARD, C. LOGIE, S. LAGADU, V. KERAVEC, D. POTTIER, F. DIONNET, J.P. MORIN, D. PRETERRE, V. ANDRE, C. MONTEIL, F. SICHEL. Toxicology in Vitro, 2017, 45, 426-433.
  • Fine and ultrafine atmospheric particulate matter at a multi-influenced urban site: physicochemical characterization, mutagenicity and cytotoxicity. Y. LANDKOCZ, F. LEDOUX, V. ANDRÉ, F. CAZIER, P. GENEVRAY, D. DEWAELE, P.J. MARTIN, C. LEPERS, A. VERDIN, L. COURCOT, S. BOUHSINA, SICHEL, M. GUALTIERI, P. SHIRALI, D. COURCOT, S. BILLET, Environmental Pollution, 2017, 221, 130-140.
  • Cytotoxicity and genotoxicity effects of arsenic trioxide on SQ20B human laryngeal carcinoma cells. TRABELSI, R. KHLIFI, D. GOUX, M. GUILLAMIN, A. HAMZA-CHAFFAI, F. SICHEL. Experimental and Toxicologic Pathology, 2017, 69, 349-358.
  • Genotoxic effects of cadmium in human head and neck cell line SQ20B. TRABELSI, R. KHLIFI, D. GOUX, M. GUILLAMIN, A. HAMZA-CHAFFAI, F. SICHEL, Environmental Science and Pollution Research, 2016, 23, 16127-16136.
  • Comparative mutagenicity and genotoxicity of particles and aerosols emitted by the combustion of standard vs. rapeseed methyl ester supplemented bio-diesel fuels. Impact of after treatment devices: Oxidation Catalyst and Particulate Filter. Mutation Research. ANDRÉ, C. BARRAUD, D. CAPRON, D. PRETERRE, V. KERAVEC, C. VENDEVILLE, F. CAZIER, J.P. MORIN, F. SICHEL, Mutation Research, 2015, 777, 33-42.
  • Xenobiotic metabolism induction and bulky DNA adducts generated by particulate matter pollution in BEAS-2B cell line: geographical and seasonal influence. LEPERS, V. ANDRÉ, M. DERGHAM, S. BILLET, A. VERDIN, G. GARÇON, D. DEWAELE, F. CAZIER, F. SICHEL, P. SHIRALI. Journal of Applied Toxicology, 2014, 34, 703-713.
  • Mutagenicity and clastogenicity of native airborne particulate matter samples collected under industrial, urban or rural influence. C. LEPERS, M. DERGHAM, L. ARMAND, S. BILLET, A. VERDIN, V. ANDRE, D. POTTIER, D. COURCOT, P. SHIRALI, SICHEL. Toxicology in Vitro, 2014, 28, 866-874.
  • Dramatic increase in oxidative stress in carbon-irradiated normal human skin fibroblasts. LAURENT, A. LEDUC, I. POTTIER, V. PRÉVOST, F. SICHEL, J.L. LEFAIX. PLoS ONE, 2013, 8, 12, e85158.
  • Polycyclic aromatic hydrocarbons-coated onto airborne particulate matter (PM2.5) produced-DNA bulky stable adducts in a human lung cell coculture model. I. ABBAS, G. GARÇON, F. SAINT-GEORGES, V. ANDRE, P. GOSSET, S. BILLET, J. LE GOFF, A. VERDIN, P. MULLIEZ, SICHEL, P. SHIRALI. Journal of Applied Toxicology, 2013, 33, 109-119.
  • Effects of alcohol consumption on biomarkers of oxidative damage to DNA and lipids in ethanol-fed pigs. PETITPAS,   F. SICHEL, B. HÉBERT,  S. LAGADU,  M. BELJEAN,  D. POTTIER, M. LAURENTIE, V. PREVOST. Experimental and Toxicologic Pathology, 2013, 65, 263-269.
  • Benzo[a]pyrene, Aflatoxin B1 and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology. PAGET, M. LECHEVREL, V. ANDRE, J. LE GOFF, D. POTTIER, S. BILLET, G. GARÇON, P. SHIRALI, F. SICHEL. PLoS ONE, 2012, 7, 2, e30921.

Contact :

ABTE-ToxEMAC, Bâtiment Recherche, Centre François Baclesse, 3 Av. Général Harris, BB5026, 14076 CAEN cedex 05

Tel 02.31.45.51.93