{"id":1870,"date":"2022-03-08T15:49:22","date_gmt":"2022-03-08T14:49:22","guid":{"rendered":"https:\/\/abte.eu\/?p=1870"},"modified":"2022-06-09T16:31:17","modified_gmt":"2022-06-09T14:31:17","slug":"offre-demploi-technicien-cdd-6-mois","status":"publish","type":"post","link":"https:\/\/abte.eu\/index.php\/2022\/03\/08\/offre-demploi-technicien-cdd-6-mois\/","title":{"rendered":"D\u00e9marrage du programme RIN RN-LEGO"},"content":{"rendered":"\n

Le projet RN-LEGO (R\u00e9seau Normand \u201cOrgan on chip Like Experimental Global Observations\u201d) vise \u00e0 d\u00e9montrer l\u2019influence de compos\u00e9s produits par le syst\u00e8me microbiote\/\u00e9pith\u00e9lium intestinal en r\u00e9ponse \u00e0 des facteurs environnementaux exog\u00e8nes comme l’antibioth\u00e9rapie sur le syst\u00e8me microbiote\/\u00e9pith\u00e9lium.<\/p>\n\n\n\n

Un biofilm de la bact\u00e9rie Enterococcus faecalis <\/em>sera cr\u00e9\u00e9 sur les cellules \u00e9pith\u00e9liales intestinales humaines Caco-2 en utilisant des souches sauvages pathog\u00e8nes et des souches mutantes d\u00e9ficientes dans le syst\u00e8me de transfert des \u00e9lectrons DMK (dim\u00e9thylm\u00e9naquinone) impliqu\u00e9 dans la production d\u2019esp\u00e8ces r\u00e9actives de l\u2019oxyg\u00e8ne. L’effet d\u2019un traitement antibiotique par l’amoxicilline sur ce biofilm sera ensuite \u00e9tudi\u00e9. Les cellules Caco-2 seront analys\u00e9es pour d\u00e9terminer si elles montrent des signes de stress oxydatif et de g\u00e9notoxicit\u00e9 qui sont des d\u00e9g\u00e2ts pr\u00e9curseurs dans le d\u00e9veloppement de cellules malignes.<\/p>\n\n\n\n

Ce projet est cofinanc\u00e9 par l\u2019Union europ\u00e9enne dans le cadre du programme op\u00e9rationnel FEDER\/ FSE 2014-2020.<\/p>\n\n\n

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Le projet RN-LEGO (R\u00e9seau Normand \u201cOrgan on chip Like Experimental Global Observations\u201d) vise \u00e0 d\u00e9montrer l\u2019influence de compos\u00e9s produits par le syst\u00e8me microbiote\/\u00e9pith\u00e9lium intestinal en r\u00e9ponse \u00e0 des facteurs environnementaux exog\u00e8nes comme l’antibioth\u00e9rapie sur le syst\u00e8me microbiote\/\u00e9pith\u00e9lium. Un biofilm de la bact\u00e9rie Enterococcus faecalis sera cr\u00e9\u00e9 sur les cellules \u00e9pith\u00e9liales intestinales humaines Caco-2 en utilisant … Continuer la lecture de « D\u00e9marrage du programme RIN RN-LEGO »<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1870","post","type-post","status-publish","format-standard","hentry","category-programmes-de-recherche"],"_links":{"self":[{"href":"https:\/\/abte.eu\/index.php\/wp-json\/wp\/v2\/posts\/1870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/abte.eu\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/abte.eu\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/abte.eu\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/abte.eu\/index.php\/wp-json\/wp\/v2\/comments?post=1870"}],"version-history":[{"count":5,"href":"https:\/\/abte.eu\/index.php\/wp-json\/wp\/v2\/posts\/1870\/revisions"}],"predecessor-version":[{"id":1922,"href":"https:\/\/abte.eu\/index.php\/wp-json\/wp\/v2\/posts\/1870\/revisions\/1922"}],"wp:attachment":[{"href":"https:\/\/abte.eu\/index.php\/wp-json\/wp\/v2\/media?parent=1870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/abte.eu\/index.php\/wp-json\/wp\/v2\/categories?post=1870"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/abte.eu\/index.php\/wp-json\/wp\/v2\/tags?post=1870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}