Pr de toxicologie
UFR Santé, Université de Caen-Normandie et CLCC François Baclesse
Thèmes de recherche :
– Cancérogenèse chimique, toxicologie génétique des polluants de l’environnement
– Toxicité de la radiothérapie et de l’hadronthérapie
Responsabilités :
Directeur de l’UR ABTE
Responsable de la mention de master « Sciences du médicament et des produits de santé » et au sein de la mention du parcours « développement clinique du médicament » ainsi que du département de Biochimie-Toxicologie de la Faculté des Sciences Pharmaceutiques de Caen.
Président de la Société Française de Toxicologie Génétique (SFTG)
Co-animateur de la Fédération de Recherche Sécurité Sanitaire et Aliments Durables de la COMUE Normandie-Université.
Sélection de publications récentes :
- Vergoz D, Nilly F, Desriac F, Barreau M, Géry A, Lepetit C, Sichel F, Jeannot K, Giard JC, Garon D, Chevalier S, Muller C, Dé E, Brunel JM.6-Polyaminosteroid Squalamine Analogues Display Antibacterial Activity against Resistant Pathogens. Int J Mol Sci. 2023 May 10;24(10):8568.
- Béchet V, Benoist H, Beau F, Divanon F, Lagadu S, Sichel F, Delépée R, Saint–Lorant G. Blood contamination of the pharmaceutical staff by irinotecan and its two major metabolites inside and outside a compounding unit. J Oncol Pharm Pract. 2022; 28(4):777-784. PMID: 33878975
- Leduc A, Chaouni S, Pouzoulet F, De Marzi L, Megnin-Chanet F, Corre E, Stefan D, Habrand JL, Sichel F, Laurent C. Differential normal skin transcriptomic response in total body irradiated mice exposed to scattered versus scanned proton beams. Sci Rep. 2021 ;11(1):5876. PMID: 33712719
- Biological Effects of Scattered Versus Scanned Proton Beams on Normal Tissues in Total Body Irradiated Mice: Survival, Genotoxicity, Oxidative Stress and Inflammation. Antioxidants (Basel). 2020 Nov 24;9(12):E1170.
- The Possibility of Using Genotoxicity, Oxidative Stress and Inflammation Blood Biomarkers to Predict the Occurrence of Late Cutaneous Side Effects after Radiotherapy. . Antioxidants (Basel). 2020, 9(3):E220.
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Nitrogen Dioxide Inhalation Exposures Induce Cardiac Mitochondrial Reactive Oxygen Species Production, Impair Mitochondrial Function and Promote Coronary Endothelial Dysfunction. Int J Environ Res Public Health. 2020; 17(15):5526.
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Comparative study on gene expression profile in rat lung after repeated exposure to diesel and biodiesel exhausts upstream and downstream of a particle filter. Environ Pollut. 2020; 266(Pt 2):115264. doi: 10.1016/j.envpol.2020.115264. PMID: 32771839
- Hadrontherapy Interactions in Molecular and Cellular Biology. Thariat J, Valable S, Laurent C, Haghdoost S, Pérès EA, Bernaudin M, Sichel F, Lesueur P, Césaire M, Petit E, Ferré AE, Saintigny Y, Skog S, Tudor M, Gérard M, Thureau S, Habrand JL, Balosso J, Chevalier F. International Journal of Molecular Sciences 2020; 21(1):133.
- An integrated functional and transcriptomic analysis reveals that repeated exposure to diesel exhaust induces sustained mitochondrial and cardiac dysfunctions. Karoui A, Crochemore C, Mulder P, Preterre D, Cazier F, Dewaele D, Corbière C, Mekki M, Vendeville C, Richard V, Vaugeois JM, Fardel O, Sichel F, Lecureur V, Monteil C. 2019 Environmental Pollution, 246:518-526.
- Evaluation of Lung Cell Toxicity of Surfactants for Inhalation Route. Lindenberg F, Sichel F, Lechevrel M, Respaud R, Saint-Lorant G. Journal of Toxicology and Risk Assessment 2019, 5:022.
- Chemical characterization of fine and ultrafine PM, direct and indirect genotoxicity of PM and their organic extracts on pulmonary cells. Billet S, Landkocz Y, Martin PJ, Verdin A, Ledoux F, Lepers C, André V, Cazier F, Sichel F, Shirali P, Gosset P, Courcot D. J Environ Sci (China). 2018 Sep;71:168-178.
- Influence of aging in the modulation of epigenetic biomarkers of carcinogenesis after exposure to air pollution. Fougère B, Landkocz Y, Lepers C, Martin PJ, Armand L, Grossin N, Verdin A, Boulanger E, Gosset P, Sichel F, Shirali P, Billet S. Exp. Gerontol. 2018 May 31.
- Comparative study of diesel and biodiesel exhausts on lung oxidative stress and genotoxicity in rats. T. DOUKI, C. CORBIERE, D. PRETERRE, P.J. MARTIN, V. LECUREUR, V. ANDRE, Y. LANDKOCZ, I. POTTIER, V. KERAVEC, O. FARDEL, S. MOREIRA-REBELO, D. POTTIER, C. VENDEVILLE, F. DIONNET, P. GOSSET, S. BILLET, C. MONTEIL, F. SICHEL. Env. Poll. 2018, 235, 514-524.
- Production of early and late nuclear DNA damage and extracellular 8-oxodG in normal human skin fibroblasts after carbon ion irradiation compared to X-rays. V. PREVOST, F. SICHEL, I. POTTIER, A. LEDUC, S. LAGADU, C. LAURENT. Toxicol In Vitro. 2018 Jun 4. doi: 10.1016/j.tiv.2018.06.004.
- Impact of after-treatment devices and biofuels on diesel exhausts genotoxicity in A549 cells exposed at air-liquid interface. C. BARRAUD, C. CORBIERE, I. POTTIER, E. ESTACE, K. BLANCHARD, C. LOGIE, S. LAGADU, V. KERAVEC, D. POTTIER, F. DIONNET, J.P. MORIN, D. PRETERRE, V. ANDRE, C. MONTEIL, F. SICHEL. Toxicology in Vitro, 2017, 45, 426-433.
- Fine and ultrafine atmospheric particulate matter at a multi-influenced urban site: physicochemical characterization, mutagenicity and cytotoxicity. Y. LANDKOCZ, F. LEDOUX, V. ANDRÉ, F. CAZIER, P. GENEVRAY, D. DEWAELE, P.J. MARTIN, C. LEPERS, A. VERDIN, L. COURCOT, S. BOUHSINA, SICHEL, M. GUALTIERI, P. SHIRALI, D. COURCOT, S. BILLET, Environmental Pollution, 2017, 221, 130-140.
- Cytotoxicity and genotoxicity effects of arsenic trioxide on SQ20B human laryngeal carcinoma cells. TRABELSI, R. KHLIFI, D. GOUX, M. GUILLAMIN, A. HAMZA-CHAFFAI, F. SICHEL. Experimental and Toxicologic Pathology, 2017, 69, 349-358.
- Genotoxic effects of cadmium in human head and neck cell line SQ20B. TRABELSI, R. KHLIFI, D. GOUX, M. GUILLAMIN, A. HAMZA-CHAFFAI, F. SICHEL, Environmental Science and Pollution Research, 2016, 23, 16127-16136.
- Comparative mutagenicity and genotoxicity of particles and aerosols emitted by the combustion of standard vs. rapeseed methyl ester supplemented bio-diesel fuels. Impact of after treatment devices: Oxidation Catalyst and Particulate Filter. Mutation Research. ANDRÉ, C. BARRAUD, D. CAPRON, D. PRETERRE, V. KERAVEC, C. VENDEVILLE, F. CAZIER, J.P. MORIN, F. SICHEL, Mutation Research, 2015, 777, 33-42.
- Xenobiotic metabolism induction and bulky DNA adducts generated by particulate matter pollution in BEAS-2B cell line: geographical and seasonal influence. LEPERS, V. ANDRÉ, M. DERGHAM, S. BILLET, A. VERDIN, G. GARÇON, D. DEWAELE, F. CAZIER, F. SICHEL, P. SHIRALI. Journal of Applied Toxicology, 2014, 34, 703-713.
- Mutagenicity and clastogenicity of native airborne particulate matter samples collected under industrial, urban or rural influence. C. LEPERS, M. DERGHAM, L. ARMAND, S. BILLET, A. VERDIN, V. ANDRE, D. POTTIER, D. COURCOT, P. SHIRALI, SICHEL. Toxicology in Vitro, 2014, 28, 866-874.
- Dramatic increase in oxidative stress in carbon-irradiated normal human skin fibroblasts. LAURENT, A. LEDUC, I. POTTIER, V. PRÉVOST, F. SICHEL, J.L. LEFAIX. PLoS ONE, 2013, 8, 12, e85158.
- Polycyclic aromatic hydrocarbons-coated onto airborne particulate matter (PM2.5) produced-DNA bulky stable adducts in a human lung cell coculture model. I. ABBAS, G. GARÇON, F. SAINT-GEORGES, V. ANDRE, P. GOSSET, S. BILLET, J. LE GOFF, A. VERDIN, P. MULLIEZ, SICHEL, P. SHIRALI. Journal of Applied Toxicology, 2013, 33, 109-119.
- Effects of alcohol consumption on biomarkers of oxidative damage to DNA and lipids in ethanol-fed pigs. PETITPAS, F. SICHEL, B. HÉBERT, S. LAGADU, M. BELJEAN, D. POTTIER, M. LAURENTIE, V. PREVOST. Experimental and Toxicologic Pathology, 2013, 65, 263-269.
- Benzo[a]pyrene, Aflatoxin B1 and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology. PAGET, M. LECHEVREL, V. ANDRE, J. LE GOFF, D. POTTIER, S. BILLET, G. GARÇON, P. SHIRALI, F. SICHEL. PLoS ONE, 2012, 7, 2, e30921.
Contact :
ABTE-ToxEMAC, Bâtiment Recherche, Centre François Baclesse, 3 Av. Général Harris, BB5026, 14076 CAEN cedex 05
Tel 02.31.45.51.93